Chris Johnson would become the first rusher to gain 100 yards against Miami in the past 23 games. He reached the milestone late in the third period and finished with 126 yards in 23 carries and one score.
Jake Locker, back after missing five games with a dislocated non-throwing shoulder, went only 9 of 21 for 122 yards but threw for touchdowns covering 9 yards to Kendall Wright and 26 yards to Jared Cook.
Colin McCarthy had a 49-yard interception return for a touchdown.
The Titans are off this week before traveling to Jacksonville on the 25th.