Matt Hasselbeck will get the start and Rusty Smith will back Hasselbeck up.
Locker dislocated his shoulder when sacked by Texans cornerback Glover Quinn early in last Sunday’s 38-14 loss.
He watched the rest of the game from the sidelines and had an MRI exam Monday.
The good news, according to Coach Mike Munchak, is Locker suffered no structural damage in the injury. When he might return is unclear.
Kick-off between the Titans (1-3) and the Vikings (3-1) is 3:25 p.m. Sunday in Minneapolis and you’ll hear it live on Thunder Radio.